Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40
Open Access
- 9 December 2008
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 100 (1) , 113-117
- https://doi.org/10.1038/sj.bjc.6604812
Abstract
SGN-40 is a therapeutic antibody targeting CD40, which induces potent anti-lymphoma activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute significantly to the therapeutic activities and that the antitumour effects of SGN-40 depend on Fc interactions.Keywords
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