Potential antitumor agents. Part 38. 3-Substituted 5-carboxamido derivatives of amsacrine
- 1 November 1983
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 26 (11) , 1619-1625
- https://doi.org/10.1021/jm00365a013
Abstract
The synthesis and biological evaluation of a series of 3-substituted 5-carboxamido derivatives of amsacrine (m-AMSA) are described. This series was developed as the result of previous quantitative structure-activity relationship (QSAR) studies of the antitumor activity of 9-anilinoacridine derivatives. In agreement with these studies, this class of compounds, possessing a variety of small nonpolar groups at the 3-position, together with very hydrophilic carboxamido groups at the 5-position, have high in vivo activity against animal [mouse] leukemia models.This publication has 15 references indexed in Scilit:
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