Thymine Dimers and Inhibition of DNA Synthesis by Ultraviolet Irradiation of Cells
- 13 December 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 142 (3598) , 1464-1466
- https://doi.org/10.1126/science.142.3598.1464
Abstract
Measurements of the inhibition of DNA synthesis in bacteria and the formation of thymine dimers by ultraviolet irradiation of the cells indicate that one thymine dimer per 350-IA strand of DNA acts as a block to further synthesis. In a sensitive strain of Escherichia coli the blocks are permanent. In a resistant strain the blocks are only temporary but recovery of synthesis is not the result of splitting dimers.Keywords
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