DISPOSITION AND PHARMACOKINETICS OF INHALED DIMETHYLAMINE IN THE FISCHER-344 RAT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 11  (5) , 417-420
Abstract
The disposition and pharmacokinetics of [14C]dimethylamine ([14C]DMA) following 6 h inhalation of 10 or 175 ppm were determined in male Fischer 344 rats. At 72 h after termination of exposure, the disposition of recovered radioactivity was similar for each airborne concentration, with > 90% in the urine and feces, 7-8% in selected tissues and the carcass, and 1.5% exhaled as 14CO2. Over 98% of the radioactivity in the urine was unmetabolized DNA. Analysis of tissue radioactivity immediately after exposure to [14C]DMA showed that the respiratory nasal mucosa contained the highest concentration of 14C, followed by the olfactory nasal mucosa; concentrations of 14C in liver, lung, kidney, brain and testes were .apprx. 2 orders of magnitude less than in the nasal mucosal tissues. Radioactivity in plasma of rats exposed by inhalation to 175 ppm [14C]DMA decayed in a biphasic manner. The terminal half-life for plasma radioactivity was similar to the half-lives of some plasma proteins, suggesting incorporation of 14C into proteins subsequent to metabolism of [14C]DMA. While most of the inhaled DMA was excreted unchanged, a small amount of oxidative metabolism of DMA occurred.

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