Determination of Amiodarone Hydrochloride in Pharmaceutical Formulations by Derivative UV Spectrophotometry and High-Performance Liquid Chromatography (HPLC)

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Abstract
Assay procedures based on derivative ultraviolet spectrophotometry and high-performance liquid chromatography (HPLC) have been developed for the specific determination of amiodarone hydrochloride in pharmaceutical dosage forms. The use of first- and second-order derivative spectrophotometry was found to have suppressed the background absorption from the excipients with comparable accuracy and precision to the reversed-phased HPLC reference method. A conventional UV absorption method (λ = 242 nm) is subject to possible interference by formulation excipients.

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