CHANGES IN COAGULATION FACTORS IN POSTMENOPAUSAL WOMEN ON ETHINYL OESTRADIOL

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Abstract
Summary: Coagulation factors II, VII, X, VII X complex and anti‐thrombin III were measured in 10 postmenopausal women before, during and after a four‐month course of 20 μg daily of ethinyl oestradiol, taken three weeks in four. Factors VII, X and VII X complex rose significantly during treatment but only factor X levels were significantly elevated at the end of the four‐month treatment period. There was no change in factor II or anti‐thrombin III levels. These effects on coagulation factors during ethinyl oestradiol therapy are, in general, similar to those found during treatment with conjugated equine oestrogens and oestradiol valerate in a previous study from the same laboratory. It seems likely that equipotent doses of ethinyl oestradiol and‘natural’oestrogens have similar effects on these coagulation factors.

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