Functional evaluation with intravoxel incoherent motion echo‐planar MRI in irradiated salivary glands: A correlative study with salivary gland scintigraphy

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Abstract
The purpose of this study was to determine the relationship between the apparent diffusion coefficient (ADC) measured on intravoxel incoherent motion (IVIM) echo‐planar magnetic resonance imaging (MRI) and salivary gland function. Twenty‐one patients with head and neck malignancies underwent MRI and salivary gland scintigraphy before and after radiotherapy. Based on the scintigraphic results, each major salivary gland was classified into two groups (dysfunctional and functional) and ADCs measured on IVIM MRI were compared between the two groups. Furthermore, the relationship of ADC to scintigraphic parameters, maximum accumulation (MA), and the uptake ratio (UR), were analyzed. ADCs of the dysfunctional group decreased significantly after radiotherapy (P < .01), whereas those of the functional group showed no significant change. Furthermore, positive correlations were found between the ADC ratio and both MA (P < .005) and UR (P < .001). ADC measurement on IVIM echo‐planar MRI is a potentially useful means of evaluating salivary gland function. J. Magn. Reson. Imaging 2001;14: 223–229.