Cerebrospinal Fluid Levels of Cyclic Nucleotides and Monoaminergic Metabolites in Subarachnoid Haemorrhage: Preliminary Report*

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Abstract
CAMP, cGMP, homovanillic acid [HVA] and 5-hydroxy-indole acetic acid [5-HIAA] levels in CSF were studied in 18 patients with subarachnoid hemorrhage (SAH). The main findings in the acute stage after SAH were represented by a marked increase of cAMP and 5-HIAA values. HVA levels were only slightly higher. In the chronic phase cGMP levels were significantly increased and were clearly related to intracranial hypertension. 5-HIAA and particularly HVA levels were decreased, probably due to the functional and anatomical lesion of the periventricular adrenergic structures, following the raised intracranial pressure.

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