There's a Problem in the Furnace
- 7 January 2004
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science of Aging Knowledge Environment
- Vol. 2004 (1) , 1
- https://doi.org/10.1126/sageke.2004.1.pe1
Abstract
A long-sought-after mutation in the manganese superoxide dismutase gene MnSOD has been isolated in Drosophila melanogaster . The MnSOD null mutation is recessive lethal, with death occurring just after eclosion. In this Perspective, I discuss these results and related work in mice within the context of the oxidative damage theory of aging.Keywords
This publication has 9 references indexed in Scilit:
- Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate agingPhysiological Genomics, 2003
- RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stressProceedings of the National Academy of Sciences, 2002
- Transgenic and mutant mice for oxygen free radical studiesPublished by Elsevier ,2002
- Mitochondrial disease in superoxide dismutase 2 mutant miceProceedings of the National Academy of Sciences, 1999
- FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster FliesMolecular and Cellular Biology, 1999
- Extension of Drosophila lifespan by overexpression of human SOD1 in motorneuronsNature Genetics, 1998
- Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injuryNature Genetics, 1996
- Gene disruptions using P transposable elements: an integral component of the Drosophila genome project.Proceedings of the National Academy of Sciences, 1995
- Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.Proceedings of the National Academy of Sciences, 1989