Protective effect of hyperbaric oxygen for the temporary ischaemic myocardium. Macroscopic and histological data
Open Access
- 31 August 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 10 (5) , 599-604
- https://doi.org/10.1093/cvr/10.5.599
Abstract
A protective effect of hyperbaric oxygen immediately after reopening of occluded coronary blood flow for the temporary ischaemic myocardial muscle was studied. Thirty dogs were used in this study, and 20 dogs were sacrificed after 4 h and 10 dogs were sacrificed after 5 d. Temporary occlusion of coronary artery (from 30 min to 2 h) was produced by ligation. One group were controls and the other group were a hyperbaric group in which dogs breathed 100% oxygen at an absolute pressure of 2 atmospheres before and after release of coronary ligation. The macroscopic extent of ischaemic area was studied by using nitroblue tetrazolium and microscopic and ECG findings were examined.Keywords
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