Genetic relationships between inbred strains of rats. An analysis based on genetic markers at 28 biochemical loci

Publisher Website
Google Scholar
Abstract
SUMMARY: Genetic similarities among 46 strains of rats based on published data involving 93 samples and 28 biochemical loci were assessed using principal coordinate and cluster analysis techniques. Seventeen strains were represented by more than one colony. In ten of these, nominally identical strains differed, and in four cases this was attributed to genetic contamination. A total of 52 genetically different strains were eventually identified. Strains BN and DA were most dissimilar, while strain BP was the most unusual strain over-all. The principal coordinate and cluster analysis showed three main clusters, which could be explained on the basis of linkage disequilibrium for some of the esterase loci in linkage group 5. Among six of these loci only 12 haplotypes were observed, with 24/52 strains having a single haplotype. Re-analysis of loci in linkage equilibrium failed to reveal any important clusters.