THE EFFECTS OF DRUGS UPON A GRADED COUGH RESPONSE OBTAINED IN SENSITIZED GUINEA PIGS EXPOSED TO AEROSOL OF SPECIFIC ANTIGEN

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Abstract
A technique is described for measuring objectively and quantitatively the reaction of sensitized guinea pigs when exposed to an aerosol of specific antigen. The principle involves registration by semi-automatic means of the number of coughs produced in animals passively sensitized with known amounts of antibody. The number of coughs is shown to be linearly related to log dose of antibody within a limited range and a dose-response curve is presented.