In vitro activity of WIN 49375 compared with those of other antibiotics in isolates from cancer patients
Open Access
- 1 September 1984
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 26 (3) , 421-423
- https://doi.org/10.1128/aac.26.3.421
Abstract
The activity of WIN 49375 [6-fluoro-1, 4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3- quinolinecarboxylic acid], a new synthetic quinolone, was tested in vitro against 587 clinical isolates. The MICs for 90% of isolates of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae were 0.20, 1.56, and 0.39 microgram/ml, respectively. The MICs for 90% of isolates of Pseudomonas aeruginosa and Serratia marcescens were both 3.12 micrograms/ml. WIN 49375 was minimally active against gram-positive cocci. Its in vitro activity suggests that it may be useful for the treatment of gram-negative bacillary infections.Keywords
This publication has 4 references indexed in Scilit:
- In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprimAntimicrobial Agents and Chemotherapy, 1983
- In vitro activity of ciprofloxacin (Bay o 9867)Antimicrobial Agents and Chemotherapy, 1983
- Norfloxacin and the antibacterial γ pyridone β carboxylic acidsJournal of Antimicrobial Chemotherapy, 1982
- Comparative in vitro activity of norfloxacin (MK-0366) and ten other oral antimicrobial agents against urinary bacterial isolatesAntimicrobial Agents and Chemotherapy, 1982