Serumspiegel und Urinausscheidung von L-Carnitin bei Patienten mit normaler und eingeschränkter Nierenfunktion

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Abstract
The influence of age, sex, and renal function on serum levels and urinary excretion of free carnitine was studied in 187 subjects. Sixty-one subjects with normal renal function (creatinine clearance >100 ml/min) showed a serum carnitine level of 72.2±23.2 µmol/l. The carnitine values of males (76.8±23.3 µmol/l,n=39) were higher (pn=49). The mean urinary carnitine excretion per day was 163.5 µmol (range 63.7–419.6 µmol) in patients with intact renal function. Extreme impairment of glomerular filtration rate (creatinine clearance n=18,pn=18,p<0.05) and a decreased carnitine clearance (0.8 ml/min, range 0.2–3.8 ml/min). These data together with earlier results obtained in dialysis patients suggest that carnitine metabolism in renal failure is altered by reduction of both endogenous carnitine biosynthesis and renal carnitine clearance.