Bacteriological Studies in Endocarditis

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Abstract
Recent advances in knowledge of anti-infectious agents have improved the outlook for successful therapy of bacterial endocarditis and a more intimate study of the bacteria concerned and of their susceptibilities to various anti-infectious agents has become of practical importance. The positive blood cultures of 36 patients included 13 examples of Streptococcus salivarius, 7 of S. equinus, 6 of S. jecalis, 3 of S. bovis, 2 in the viridans group unspecified, 2 in the micrococcus group unspecified, 1 Staphylococcus aureus, 1 Actinomyces septicus (n.sp.) and 1 Gram-negative rod unclassified. These were unselected but nevertheless not considered representative. The streptococci of the salivarius, equinus and bovis groups were susceptible to penicillin and resistant to bacteriophages, in contrast to those of the fecalis group, which were resistant to penicillin and susceptible to bacteriophages. There were also marked differences in susceptibility to neoarsphenamine and NaBi thioglycollate. Possible development of drug-fastness during treatment was encountered and the problem presented by this has not been fully solved.

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