The effect of hemodialysis and hemoperfusion on serum valproic acid concentration
- 31 August 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 40 (9) , 1456
- https://doi.org/10.1212/wnl.40.9.1456
Abstract
We report a patient with dialysis-induced encephalopathy who was taking divalproex sodium for a seizure disorder. Her serum valproic acid concentration appeared to be in the low therapeutic range at 54 mg/l yet she continued to have seizure activity. The elimination half-life and apparent clearance of valproic acid were the same for both a dialysis and nondialysis day, indicating that hemodialysis/hemoperfusion has little effect on the overall removal of valproic acid from the body.This publication has 2 references indexed in Scilit:
- Valproate plasma protein binding in the uremic conditionClinical Pharmacology & Therapeutics, 1980
- Plasma Protein Binding of Phenytoin and Warfarin in Patients Undergoing Renal Transplantation1Clinical Pharmacokinetics, 1977