Reticulin antibodies in patients with coeliac disease and their relatives.
- 1 August 1975
- Vol. 16 (8) , 598-602
- https://doi.org/10.1136/gut.16.8.598
Abstract
The sera of 69 index coeliac patients, 121 of their first-degree relatives, and 104 controls were screened for the presence of reticulin antibodies. Among the untreated coeliac patients 75% of adults and 93% of children had reticulin antibody in their serum. Reticulin antibody was not present in any adequately treated coeliac patient. Of the first-degree relatives, 21 were reticulin antibody positive; 17 of these were biopsied and 12 were shown to have coeliac disease. Sixty-five of the coeliac relatives who did not have reticulin antibodies in their sera were biopsied and two had coeliac disease. Of the 68 relatives and 63 controls with normal biopsies, five of the relatives and four of the controls were reticulin antibody positive.Keywords
This publication has 35 references indexed in Scilit:
- The cell population of the upper jejunal mucosa in tropical sprue and postinfective malabsorptionGut, 1974
- Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's diseaseGut, 1974
- Antireticulin antibody: Incidence and diagnostic significanceGut, 1973
- Incidence of Coeliac Disease in the West of IrelandBMJ, 1973
- RETICULIN ANTIBODY IN CHILDREN WITH MALABSORPTIONThe Lancet, 1972
- Precipitins to Dietary Proteins in Serum and Upper Intestinal Secretions of Coeliac ChildrenBMJ, 1972
- Incidence of small-intestinal mucosal abnormalities and of clinical coeliac disease in the relatives of children with coeliac diseaseGut, 1971
- AUTOANTIBODIES TO RETICULIN IN PATIENTS WITH IDIOPATHIC STEATORRHŒA, CŒLIAC DISEASE, AND CROHN'S DISEASE, AND THEIR RELATION TO IMMUNOGLOBULINS AND DIETARY ANTIBODIESThe Lancet, 1971
- UNIQUE ANTIBODY TO BASEMENT MEMBRANE IN PATIENTS WITH SELECTIVE IgA DEFICIENCY AND CŒLIAC DISEASEThe Lancet, 1971
- Immunoglobulins and dietary protein antibodies in childhood coeliac diseaseGut, 1970