Carcinogenic Activity of Symphytum officinale2
- 1 September 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 61 (3) , 865-869
- https://doi.org/10.1093/jnci/61.3.865
Abstract
The carcinogenicity of Symphytum officinale L., Russian comfrey, used as a green vegetable or tonic, was studied in inbred ACI rats. Three groups of 19–28 rats each were fed comfrey leaves for 480–600 days; four additional groups of 15–24 rats were fed comfrey roots for varying lengths of time. A control group was given a normal diet. Hepatocellular adenomas were induced in all experimental groups that received the diets containing comfrey roots and leaves. Hemangioendothelial sarcoma of the liver was infrequently induced.Keywords
This publication has 2 references indexed in Scilit:
- Carcinogenic Activity of Petasitenine, a New Pyrrolizidine Alkaloid Isolated From Petasites japonicus Maxim2JNCI Journal of the National Cancer Institute, 1977
- The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine, and their N‐oxidesThe Journal of Pathology and Bacteriology, 1959