Quantitative analysis of intracranial circulation using rapid-sequence DSA

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Abstract
By using a high-frame-rate technique, intravenous digital subtraction angiography (IVDSA) of the intracranial circulation was performed in patients with transient ischemic attacks and asymptomatic bruits. Twenty patients with normal carotid arteries or mild stenosis of no hemodynamic significance were selected as a control group to evaluate the effect of carotid stenosis on the difference between hemispheres in the peak arrival time (delta TMAX) of the contrast bolus. Data were obtained for the anterior (ACA), middle (MCA), and posterior (PCA) cerebral artery distributions. Raw data of the time-density curve in a region of interest were analyzed by polynomial curve-fitting techniques to obtain the peak arrival time (TMAX). The delta TMAXs for normal middle, anterior, and posterior distributions were 0.140 +/- 0.119 sec, 0.152 +/- 0.146 sec, and 0.189 +/- 0.187 sec, respectively. Eleven patients with tight carotid stenosis or occlusion whose delta TMAX fell outside the normal range as established from the ...