Suppression of liver uptake of liposomes by dextran sulfate 500.

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Abstract
The effect of dextran sulfate (DS, 500,000 MW) and multilamellar vesicles (MLV) as liver blockade agent was investigated in mice. I.v. injection of unlabeled MLV prior to radioactive MLV caused moderate reduction in the liver uptake and increased tibia, lung and spleen uptake. More drastic differences were observed with i.p. injection of DS. When tested in the range of 0-50 mg DS/kg body weight, maximal liver blockade occurred at a dose of 50 mg. By using 50 mg DS/kg, maximal liver blockade occurred 12 h after DS injection. The liver blockade was temporary, ending within 48 h. The i.p. route of injection for DS was more effective for liver blockade than the i.v. route.