Effect of 9-hydroxylation on benzomorphan antagonist activity
- 1 June 1975
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 18 (6) , 619-621
- https://doi.org/10.1021/jm00240a019
Abstract
In a benzomorphan bearing an antagonist side chain, introduction on the methano bridge of a hydroxyl oriented away from nitrogen has little effect on antagonist activity whereas a hydroxyl oriented toward nitrogen enhances this activity. Hydroxylation tends to decrease analgesic activity.Keywords
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