X-rays Affect the Incorporation of 5-Iododeoxyuridine into Deoxyribonucleic Acid
- 7 April 1961
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 133 (3458) , 1074-1075
- https://doi.org/10.1126/science.133.3458.1074
Abstract
When labeled with iodine-131, 5-iododeoxyuridine, an analogue of thymidine, is useful in estimating the effect of x-radiation on deoxyribonucleic acid metabolism. Although this compound is readily incorporated into deoxyribonucleic acid in the absence of ionizing radiation, we find that whole-body exposure to as little as 10 r will significantly inhibit its incorporation.Keywords
This publication has 4 references indexed in Scilit:
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- Incorporation of 5-Iodouracil labelled with Iodine-131 into the Deoxyribonucleic Acid of Human Leukæmic Leucocytes following in vivo Administration of 5-Iododeoxyuridine labelled with Iodine-131Nature, 1959
- Synthesis and biological activities of iododeoxyuridine, an analog of thymidineBiochimica et Biophysica Acta, 1959