Effect of drugs on experimental brain edema in mice

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Abstract
✓ Cold-induced hemorrhagic infarcts in mice caused a spreading decrease in tissue specific gravity around the lesion; the decrease in tissue density represents an increase in edema fluid. The maximum decrease in density in most brain areas had occurred by 6 hours. This time period was used to evaluate the effect of nine drugs on brain edema. Two agents increased edema formation: hexamethonium and meralluride. Metaraminol, cortisone, hydrocortisone, acetazolamide, and dextran did not significantly alter edema formation. Only in the phenoxybenzamine- and urea-treated mice was brain edema less than in the control mice.