Fibrinogen ? proteolysis in acute myelogenous leukemia (AML)

Abstract
Fibrinopeptides were measured as direct indices of thrombin, plasmin and elastase in plasma samples obtained from patients with AML. Peptide patterns observed were consistent with spontaneous or drug induced plasmin-specific fibrinogenolysis (AML FAB M 1/3), elastase mediated proteolysis (AML FAB M 3/4) or DIC (AML FAB M 4/5). DIC was also observed in septic, agranulocytotic patients.