The Effects of Adherence to Antidepressant Treatment Guidelines on Relapse and Recurrence of Depression

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Abstract
THERE HAVE BEEN major advances in the treatment of depressive illnesses during the past decade. Adequate pharmacological or psychotherapeutic treatments are accessible to increasing numbers of patients. However, depressive disorders are still associated with high rates of relapse and recurrence during a patient's lifetime. The National Institute of Mental Health Consensus Development Conference on relapse and recurrence of depression found that 50% to 85% of people who have an episode of depression will suffer a recurrent episode during their lifetime. Of these, 50% will experience recurrence within 2 years of the initial episode.1

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