THE PRESSOR RESPONSE TO ADRENALIN IN THE COURSE OF TRAUMATIC SHOCK

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Abstract
Exptl. traumatic shock was produced in the anaesthetized cat by multiple fractures of the bones of a hind limb. Significant local fluid loss was prevented by bandaging the limb with tape, the avg. local fluid loss amounting to 0.65% of the body wt. Following trauma, the blood pressure fell progressively, resulting in death in 2 1/2 hrs. In such expts., shock did not supervene when the limb was traumatized following transection of the upper lumbar spinal cord. Adrenalin was injected in physiological dosage every 15 mins. during the course of shock. The rise of blood pressure produced by adrenalin was greater during the course of shock than before trauma. Two to fourteen mins. before death blood pressure suddenly failed to respond to adrenalin. This terminal loss of responsiveness to adrenalin was correlated with a spontaneous terminal outburst of sympathetic activity. These expts. provide no support to the theory that hyperactivity of the sympathetic nervous system is responsible for the type of shock resulting from afferent nerve impulses.

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