Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. V. Generation of hydroxyl radical by sporidesmin
- 31 January 1987
- journal article
- research article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 7 (1) , 17-22
- https://doi.org/10.1002/jat.2550070105
Abstract
Sporidesmin, the mycotoxin responsible for ‘facial eczema’ in ruminants, has previously been shown to generate superoxide radical and hydrogen peroxide. In the present study, the formation of the third ‘active oxygen’ species, hydroxyl radical, has been demonstrated. This species is produced both during the autoxidation of the reduced (dithiol) form of the mycotoxin and in the cyclic reduction/autoxidation reaction between sporidesmin and glutathione. In view of the exceptional reactivity of the hydroxyl radical, this substance may be the proximate agent responsible for the toxic effects of sporidesmin.Keywords
This publication has 28 references indexed in Scilit:
- Studies on the mechanism of toxicity of the mycotoxin sporidesmin. IV. Inhibition by copper-chelating agents of the generation of superoxide radical by sporidesminJournal of Applied Toxicology, 1985
- Studies on the mechanism of toxicity of the mycotoxin sporidesmin. 2—evidence for intracellular generation of superoxide radical from sporidesminJournal of Applied Toxicology, 1984
- Mitomycin C-induced deoxyribose degradation inhibited by superoxide dismutaseFEBS Letters, 1984
- The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytesBiochimica et Biophysica Acta (BBA) - General Subjects, 1982
- Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. I. Generation of superoxide radical by sporidesminChemico-Biological Interactions, 1982
- Deoxyribose breakdown by the adriamycin semiquinone and H2O2: evidence for hydroxyl radical participationFEBS Letters, 1982
- Mitochondrial Formation of OH˙ Radicals by an Ubisemiquinone-Dependent Reaction An Alternative Pathway to the Iron-Catalysed Haber-Weiss CycleHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1982
- Production of hydroxyl radicals from paraquat radicals and H2O2FEBS Letters, 1981
- Radiolysis of Glutathione in Oxygen-containing Solutions of pH 7International Journal of Radiation Biology, 1977
- A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solutionThe International Journal of Applied Radiation and Isotopes, 1967