Extracellular ascorbate modulates glutamate dynamics: role of behavioral activation
Open Access
- 16 May 2007
- journal article
- Published by Springer Nature in BMC Neuroscience
- Vol. 8 (1) , 32
- https://doi.org/10.1186/1471-2202-8-32
Abstract
A physiological increase in extracellular ascorbate (AA), an antioxidant vitamin found throughout the striatum, elevates extracellular glutamate (GLU). To determine the role of behavioral arousal in this interaction, microdialysis was used to measure striatal GLU efflux in rats tested in either a lights-off or lights-on condition while reverse dialysis either maintained the concentration of AA at 250 μM or increased it to 1000 μM to approximate endogenous changes.Keywords
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