Peptide Hormone-Induced Receptor Mobility, Aggregation, and Internalization

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Abstract
ONE of the basic challenges facing modern biomedical research is the understanding of how hormones produce chemical signals that cause alterations in cellular metabolism. Peptide hormones induce a host of responses in their target tissues through selective interactions with cell-surface receptors.1 Some of these responses occur immediately, but others are considerably delayed. Even though many of these metabolic changes may arise concomitantly, all responses have a rigorous temporal orientation with respect to others. To date, it has remained elusive how any single peptide hormone can regulate such diverse types of responses and how temporal control of these responses is mediated. . . .