Reflections on the Pathologic Physiology of Atherosclerosis

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Abstract
Serum Lipids and AtherogenesisWith this necessarily sketchy discussion of lipid physiology as a background, it is appropriate to consider what the relation of the serum lipids and atherosclerosis might be. Since most lipids travel in the circulation in the form of lipoprotein complexes, they presumably precipitate or dissociate within the intima in the same form.§ If this assumption is correct, it becomes mandatory to attempt to determine the conditions under which such lipid precipitation might take place.These conditions have not been adequately defined. However, animal experiments have shown that when an increased serum concentration of cholesterol-rich lipoproteins is . . .