Mycoplasmal Arthritis of the Mouse: Development of Cellular Hypersensitivity to Normal Synovial Tissue

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Abstract
Cellular hypersensitivity to normal mouse synovial tissue was found in arthritic mice infected by iv injection of Mycoplasma pulmonis but not in uninfected normal mice. Hypersensitivity was determined by inhibition of migration of peritoneal macrophages in the presence of an antigen made from normal mouse synovium. Since, in a previous study, no correlation was found between the presence of mycoplasmas in arthritic joints and the extent of arthritis, this data suggests that both microbiological and immunological mechanisms are involved in the pathogenesis of the disease.

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