One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta
- 26 February 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 261 (2) , 327-330
- https://doi.org/10.1016/0014-5793(90)80583-5
Abstract
A cDNA encoding human endothelin 3 (ET-3) precursor was cloned from a cDNA library from the placenta, and its nucleotide and deduced amino acid sequences were determined. This ET-3 cDNA was found to contain 2.3 kb pairs and encode prepro-ET-3 protein consisting of 224 amino acid residues. The putative big-ET-3 seems to consist of 42 amino acid residues. Two of the intron insertion sites were determined with information from nucleotide sequences of the cloned genomic ET-3 gene. This is the first direct evidence that the ET-3 gene is transcribed and expressed in the placenta.Keywords
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