2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

This publication has 17 references indexed in Scilit:

• Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis
  Nature Biotechnology, 2000
• Antisense therapeutics: is it as simple as complementary base recognition?
  Molecular Medicine Today, 2000
• Morpholino antisense oligomers: the case for an RNase H-independent structural type
  Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999
• A review of issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides
  Published by Elsevier ,1999
• Antisense oligonucleotides as a tool for gene functionalization and target validation
  Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999
• 2′-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation
  Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999
• Peptide nucleic acids as therapeutic agents
  Current Opinion in Structural Biology, 1999
• Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides
  Tetrahedron Letters, 1998
• Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering
  Tetrahedron Letters, 1997
• The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes
  Nucleic Acids Research, 1997