Frusemide enhancement of netilmicin nephrotoxity in dogs

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Abstract
Male mongrel dogs were given netilmicin (15 mg/kg) i.m. every 8 h for 10 days, or netilmicin (15 mg/kg)+ frusemide (2 mg/kg) i.m. every 8 h for 8 days. Dogs receiving netilmicin alone had minimal changes in renal function and histology. Dogs receiving netilmicin together with frusemide developed marked elevations in BUN (88·1 ± 24·1 v. 17·0 ± 1·4 mg/dl, P P N-acetyl-β-glucosaminidase and β glucuronidase activities were comparable to levels in dogs receiving netilmicin alone, but muramidase activity was significantly higher (223 ± 63 v. 58 ± 14 U, P<0·05). In summary, frusemide enhances the nephrotoxicity of netilmicin, probably largely due to volume depletion.

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