Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry
- 12 October 2007
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 5 (23) , 3805-3813
- https://doi.org/10.1039/b710348d
Abstract
The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′-iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′,3′-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary.Keywords
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