New Platelet Antigen, Sib^a, Involved in Platelet Transfusion Refractoriness in a Japanese Man

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Abstract
Sib^a, a new platelet-specific alloantigen involved in a case of platelet transfusion refractoriness is reported. The IgG platelet alloantibody was detected in a multiply transfused patient of Japanese extraction (Sib), by the presence of HLA antibodies. After transfusion of HLA-compatible platelets, the patient suffered from refractoriness. Adsorption studies with pooled lymphocytes showed that the serum contained anti-platelet activity. Family studies indicate that Sib^a is inherited as an autosomal codominant trait and separate from HLA and Bak^a. As of this report, segregation from Zw (P1^A) and Yuk (Pen) antigen systems have not yet been determined. The gene frequency of Sib^a in the Japanese population is estimated to be 0.136.

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