External Therapeutic Use of Radioactive Phosphorus

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Abstract
For the study of the skin effects of radioactive P, 69 exposures were made on the forearm and arm of 12 healthy subjects. The radioactive P was applied by using disks of blotting paper 2.5 cm in diam. and 0.4 mm thick, soaked with Na2HPO4 soln. Radioactive P applied to skin in this manner produces erythemata showing a monophasic course. The intensity of the erythema depends on the amt. of exposure. "Threshold erythema" was produced by an exposure to 34 microcurie hrs./square cm. Dry, scale epidermite was pro-duced by an exposure to 2,000 microcurie hrs./cm2; and bul-lous epidermite resulted from an exposure to 4,400 microcurie hrs./cm2. The depth of discernible biologic effect from externally applied radioactive P is approx. 5 mm for erythema producing doses.

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