Quantitative Study of Liver Metastases From Colon Cancer in Rats After Treatment With Cyclosporine A2
- 1 July 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 77 (1) , 227-232
- https://doi.org/10.1093/jnci/77.1.227
Abstract
Liver metastases were produced in syngeneic BD IX rats by intraportal injection of colon,cancer cell aggregates. The cells originated from the DHD/K12 cell line, derived from a 1,2-dimethylhydrazine (CAS: 540-73-8)-induced colon adenocarcinoma in BD IX rats. The animals received either cyclosporine A (CSA) or the excipiens alone (control) through daily gastric intubation during 6 weeks. Multiple and very large hepatic metastases were observed early in 100% of the CSA-treated rats. The mean tumor volume was approximately 2,000 times higher in the CSAtreated group than in the controls (P<.01). Survival time in the CSA-treated group was shortened (P<.01) by generalized metastatic disease. Easy production of metastasis from colon cancer in 100% of the animals and precise estimation of tumor volume may prove useful for future therapeutic studies of secondary hepatic disease.Keywords
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