Distribution of endotoxin-51-Cr in normal and endotoxin-resistant dogs

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Abstract
Although the dog has been extensively employed in studies on endotoxin shock, information is lacking on the fate of endotoxin in this species. Plasma clearance and tissue distribution were investigated in normal and endotoxin-resistant dogs using E.[Escherichia] coli endotoxin labeled with chromate 51 (51Cr). Endotoxin disappeared exponentially from the peripheral circulation in a similar way in normal and endotoxin-resistant animals. Higher endotoxin concentrations were found in mesenteric vein plasma and thoracic lymph of normal dogs. The greater venous concentration was probably related to increased splanchnic pooling. The highest tissue levels in both groups were in liver and spleen, with lower but significant amounts in lungs, mesentric lymph nodes, kidneys, and adrenals. In whole blood, endotoxin was confined to plasma and buffy coat. Resistant dogs had more endotoxin in liver, spleen, lungs, and kidneys, and greater urine radioactivity. Contrary to clearances in rabbits and mice, there is no diffference in the peripheral clearing of endotoxin in normal and resistant dogs.

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