Rate of Urinary Fluoride Output in Normal Adults

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Abstract
Urine samples were collected at ten intervals during a 24-hour period from 8 normal adults drinking 1 ppm F and receiving a single "challenge" dose of 5 mg F as NaF in 200 ml of water (test day). The total fluoride output after each time interval was compared with that found at a similar time during the previous 24-hour period (control day) when 1 ppm F alone was ingested in the drinking water. After 24 hours, 65.1% of the fluoride ingested during the control day appeared in the urine, whereas only 54.1% of the intake during the test day was found. Fluoride was eliminated with the greatest rapidity during the first hour after ingestion of a "challenge" dose of 5 mg F. Thereafter, the rate dropped rapidly for an additional 8 hours and then asymptotically approached the rate of 0.1 [mu]g/hour observed during the control day.

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