Synthetic Neuromedin C Stimulates Exocrine Pancreatic Secretion in Dogs and Rats

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Abstract
We have examined the effect of neuromedin C on exocrine pancre-atic secretion both in vivo and in vitro, and compared its bioactivity with those of related peptides. In anesthetized dogs, neuromedin C caused a dose-depen-dent initial reduction of pancreatic blood flow and an increase in secretin-stim-ulated exocrine pancreatic secretion, and had almost the same potency as gas-trin-releasing peptide (GRP) in decreasing pancreatic blood flow. A potent stimulatory effect on exocrine pancreatic secretion was found in conscious dogs accompanied by a significant elevation in the circulating cholecystokinin (CCK) levels. In isolated rat pancreatic acini, amylase was released dose-de-pendently in response to neuromedin C. This study demonstrates that neuro-medin C (a smaller molecular form of GRP) possesses potent bioactivity on exocrine pancreas and suggests that two factors may be involved in the mecha-nism by which this peptide effects exocrine secretion, namely; (a) direct stimu-lation on acinar cells and (b) stimulation of CCK release.

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