A Facile and Practical Synthesis of 1-Aryl-3,3,3-trifluoropropynes
- 15 April 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 62 (4) , 1352-1354
- https://doi.org/10.1246/bcsj.62.1352
Abstract
A facile and practical method for the synthesis of ArC≡CCF3 is described which involves (1) conversion of aldehydes ArCHO into ArCH=CClCF3 with 1,1,1-trichloro-2,2,2-trifluoroethane, zinc powder, and acetic anhydride in one-pot and (2) dehydrochlorination with sodium t-butoxide or sodium amide/t-butyl alcohol.Keywords
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