AIRWAY RESPONSES TO SULFUR-DIOXIDE AND METHACHOLINE IN ASTHMATICS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 27  (4) , 265-268
Abstract
SO2 is a common air pollutant found in the workplace. Considerable variation exists in the airway responses of asthmatics to the inhalation of SO2. To determine if such variation among asthmatics was related to nonspecific airway reactivity, the threshold doses of methacholine and SO2 required to produce significant changes in flow rates at 60% of the vital capacity below total lung capacity on the partial expiratory flow volume curve was compared in a group of 8 mildly asthmatic subjects. A significant correlation between the dose of SO2 and the dose of methacholine requried to produce bronchoconstriction (r = 0.86, P < 0.05) was observed, suggesting that there was a relationship between the response to SO2 and the response to methacholine in mildly asthmatic individuals. More generally, nonspecific airway hyperreactivity may help to predict untoward airway responses to inhaled SO2 in the workplace.

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