4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation

1 November 1994

journal article
Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry

Vol. 37 (24) , 4258-4260
https://doi.org/10.1021/jm00050a023

Abstract

4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.

Keywords

DEACETYLTAXOTERE
III
TRIETHYLSILYL
DEACETYLBACCATIN
ANALOGS
DEACETYLTAXOL
SYNTHESIS AND BIOLOGICAL
BIOLOGICAL EVALUATION
ASSEMBLY ASSAY

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