Immunoglobulin G: Potentiation of Tobramycin and Azlocillin in the Treatment of Pseudomonas aeruginosa Sepsis in Neutropenic Mice and Neutralization of Exotoxin A in Vivo
- 1 July 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 8 (Supplement) , S420-S425
- https://doi.org/10.1093/clinids/8.supplement_4.s420
Abstract
Mice with cyclophosphamide-induced neutropenia were challenged with four immunotypes of Pseudomonas aeruginosa by contamination of a small dorsal surface wound. The infections were lethal; 100% of control animals (n = 80) treated only with albumin died. Administration of an immunoglobulin G intravenous preparation (IGIV) and/or therapy with tobramycin or azlociIlin was begun 16 hr after challenge. Mortality among mice (n = 120)treated only with an antibiotic was 75.0%, while that among mice (n = 80) treated only with IGIV was 78.8%. Combination therapy with IGIV and an antibiotic (n = 120) resulted in mortality of 38.3%. The protection afforded by IGIV may have resulted in part from neutralization of exotoxin A, as mice treated with IGIV before challenge with exotoxinA weresubject to lowermortality and had lowerlevelsof serum aspartate and alanine aminotransferases than controls.Keywords
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