Template‐Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn‐Inducing Mimics
- 30 June 1993
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 76 (4) , 1539-1563
- https://doi.org/10.1002/hlca.19930760414
Abstract
The 8‐amino‐5,6,7,8‐tetrahydronaphth‐2‐oic acid (1), 8‐(aminomethyl)‐5,6,7,8‐tetrahydronaphth‐2‐oic acid (2), and 8‐(aminomethyl)naphth‐2‐oic acid (3) were synthesized in their protected forms as turn‐inducing dipeptide mimics. Two of them (2 and 3) were incorporated into a novel type of cyclic, peptide‐based structures (see 21 and 34–36) designed as templates for the synthesis of TASP molecules.Keywords
This publication has 12 references indexed in Scilit:
- Molecular dynamics conformational search of six cyclic peptides used in the template assembled synthetic protein approach for protein de novo designBiopolymers, 1992
- Preparative chromatographic separation of enantiomersJournal of Chromatography B: Biomedical Sciences and Applications, 1992
- Template-assembled synthetic proteins with four-helix-bundle topology. Total chemical synthesis and conformational studiesJournal of the American Chemical Society, 1992
- Three novel mimics for the construction of sterically constrained protein turn modelsTetrahedron Letters, 1990
- Synthesis of a 4-helix bundle-like template-assembled synthetic protein (TASP) by condensation of a protected peptide on a conformationally constrained cyclic carrierTetrahedron Letters, 1990
- Design and synthesis of a protein .beta.-turn mimeticJournal of the American Chemical Society, 1990
- The de novo design of protein structuresTrends in Biochemical Sciences, 1989
- A Chemical Approach to Protein Design—Template‐Assembled Synthetic Proteins (TASP)Angewandte Chemie International Edition in English, 1989
- Ein chemischer Weg zu neuen Proteinen – Templat‐assoziierte synthetische Proteine (TASP)Angewandte Chemie, 1989
- 890. Friedel–Crafts acylation and alkylation. A comparison of inter- and intra-molecular processesJournal of the Chemical Society, 1956