Effect of Riboflavin Deficiency on Endochondral Ossification of Mice.

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Abstract
In growing mice, riboflavin deficiency decreases both the rate of growth and of ossification, but intensifies the degeneration of the cartilage. These changes represent the histologic basis for the inhibition of lengthwise growth seen in riboflavin-deficient animals. As compared with the changes seen in pantothenic acid deficiency, lack of riboflavin inhibits the proliferation of the cartilage to a lesser extent, whereas it produces degeneration of the cartilage, not seen in pantothenic acid deficiency. As in pantothenic acid deficiency, [female][female] are more sensitive to the lack of the vit. than are [male][male] . In adult mice, the endosteal and periosteal osteoblasts undergo atrophy.

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