INCREASE OF 5‐HYDROXYTRYPTAMINE IN THE RAT BRAIN BY RAUNESCINE
Open Access
- 1 June 1959
- journal article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 14 (2) , 164-167
- https://doi.org/10.1111/j.1476-5381.1959.tb01377.x
Abstract
The Rauwolfia alkaloid raunescine (5 mg./kg., intraperitoneally) increased the concentration of 5‐hydroxytryptamine in the brains of rats after iproniazid pre‐treatment. This was evident 3 to 4 hr. after raunescine administration. There was no general increase in the noradrenaline content of the brains. In the intestine, raunescine depleted the 5‐hydroxytryptamine content by about 50% within 3 to 4 hr. if the animals had been pre‐treated with iproniazid. Iproniazid did not increase the content of noradrenaline in the intestine.Keywords
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