Special Therapeutics: Physiology of Diuretics

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Abstract
Chlorothiazide has been by far the most intensely employed of the benzothiadiazines, and its utility and safety are well documented. Hydrochlorothiazide, from a dosage standpoint, is some 10 times as potent as chlorothiazide. However, the 2 compounds are equally effective when employed in equivalent dosages. Both of these compounds cause a profound saluresis of much the same duration when administered orally. Both agents cause a hypokalemia secondary to an increase in excretion of K in some patients, especially when employed at high dosages. The trifluoromethyl analogues of these 2 agents are slightly less active by critical assay than are their chloro analogues. They seem to offer no advantage over chlorothiazide or hypochlorothiazide from the standpoint of utility or safety.