Recovery of the Virus of Lymphocytic Choriomeningitis from the Erythrocytes of Infected Animals
Open Access
- 1 February 1944
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 48 (2) , 111-127
- https://doi.org/10.4049/jimmunol.48.2.111
Abstract
Summary: The virus of lymphocytic choriomeningitis may be found in association with the erythrocytes of mice and guinea-pigs during the experimental disease. The concentration of the virus in the erythrocytes has no relation to the amount present in the blood serum and the washings of the erythrocytes. The association is firm, apparently taking place in the stroma of the red blood cells. Strains of the virus differ from one another in the ability to attach themselves to the erythrocytes of mice and guinea-pigs. When a strain shows a decidedly greater virulence for one species than the other, there is observed a consistent infectivity of erythrocytes of the species for which the virulence of the strain is greater. The virus may be recovered only irregularly from the erythrocytes of mice and guinea-pigs when the infecting strain shows low virulence for both animal species.Keywords
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